Category:PK
From Metabolomics.JP
(Difference between revisions)
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{| | {| | ||
|- | |- | ||
| − | | [[Image:1,3,8-Trihydroxyaceto-Naphthalene.Mol]] | + | | 1,3,8-Trihydroxyaceto-Naphthalene |
| + | | [[Image:1,3,8-Trihydroxyaceto-Naphthalene.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:1,3-Dihydroxy-N-Methylacridone.Mol]] | + | | 1,3-Dihydroxy-N-Methylacridone |
| + | | [[Image:1,3-Dihydroxy-N-Methylacridone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:3,8-Dihydroxy-1-Methylanthraquinone-2-Carboxylic_Acid.Mol]] | + | | 3,8-Dihydroxy-1-Methylanthraquinone-2-Carboxylic_Acid |
| + | | [[Image:3,8-Dihydroxy-1-Methylanthraquinone-2-Carboxylic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:4-Hydroxy-2-Quinolone.Mol]] | + | | 4-Hydroxy-2-Quinolone |
| + | | [[Image:4-Hydroxy-2-Quinolone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:5,7-Dihydroxy-2-Methylchromone.Mol]] | + | | 5,7-Dihydroxy-2-Methylchromone |
| + | | [[Image:5,7-Dihydroxy-2-Methylchromone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:5-Methylorsellinic_Acid.Mol]] | + | | 5-Methylorsellinic_Acid |
| + | | [[Image:5-Methylorsellinic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:6-Deoxy-Erythronolide_B.Mol]] | + | | 6-Deoxy-Erythronolide_B |
| + | | [[Image:6-Deoxy-Erythronolide_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:6-Methoxymellein.Mol]] | + | | 6-Methoxymellein |
| + | | [[Image:6-Methoxymellein.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:6-Methyl_Salicylic_Acid.Mol]] | + | | 6-Methyl_Salicylic_Acid |
| + | | [[Image:6-Methyl_Salicylic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Actinorhodin.Mol]] | + | | Actinorhodin |
| + | | [[Image:Actinorhodin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Adhyperforin.Mol]] | + | | Adhyperforin |
| + | | [[Image:Adhyperforin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aflatoxin_B1.Mol]] | + | | Aflatoxin_B1 |
| + | | [[Image:Aflatoxin_B1.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aflatoxin_B2.Mol]] | + | | Aflatoxin_B2 |
| + | | [[Image:Aflatoxin_B2.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aflatoxin_G1.Mol]] | + | | Aflatoxin_G1 |
| + | | [[Image:Aflatoxin_G1.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aflatoxin_G2.Mol]] | + | | Aflatoxin_G2 |
| + | | [[Image:Aflatoxin_G2.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aflatoxin_M1.Mol]] | + | | Aflatoxin_M1 |
| + | | [[Image:Aflatoxin_M1.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aloe-Emodin.Mol]] | + | | Aloe-Emodin |
| + | | [[Image:Aloe-Emodin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aloesaponarin_II.Mol]] | + | | Aloesaponarin_II |
| + | | [[Image:Aloesaponarin_II.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Alternapyrone.Mol]] | + | | Alternapyrone |
| + | | [[Image:Alternapyrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Alternaric_Acid.Mol]] | + | | Alternaric_Acid |
| + | | [[Image:Alternaric_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Alternariol.Mol]] | + | | Alternariol |
| + | | [[Image:Alternariol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Amphotericin_B.Mol]] | + | | Amphotericin_B |
| + | | [[Image:Amphotericin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Andrimid_.Mol]] | + | | Andrimid_ |
| + | | [[Image:Andrimid_.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ascomycin.Mol]] | + | | Ascomycin |
| + | | [[Image:Ascomycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aslaniol.Mol]] | + | | Aslaniol |
| + | | [[Image:Aslaniol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aslanipyrone.Mol]] | + | | Aslanipyrone |
| + | | [[Image:Aslanipyrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Asperlactone.Mol]] | + | | Asperlactone |
| + | | [[Image:Asperlactone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Asperlin.Mol]] | + | | Asperlin |
| + | | [[Image:Asperlin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aspyridone_A.Mol]] | + | | Aspyridone_A |
| + | | [[Image:Aspyridone_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aspyridone_B.Mol]] | + | | Aspyridone_B |
| + | | [[Image:Aspyridone_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aspyrone.Mol]] | + | | Aspyrone |
| + | | [[Image:Aspyrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Asteltoxin.Mol]] | + | | Asteltoxin |
| + | | [[Image:Asteltoxin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Astepyrone.Mol]] | + | | Astepyrone |
| + | | [[Image:Astepyrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Atrochrysone.Mol]] | + | | Atrochrysone |
| + | | [[Image:Atrochrysone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Atrochrysone_Carboxylic_Acid.Mol]] | + | | Atrochrysone_Carboxylic_Acid |
| + | | [[Image:Atrochrysone_Carboxylic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Aureothin.Mol]] | + | | Aureothin |
| + | | [[Image:Aureothin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Austdiol.Mol]] | + | | Austdiol |
| + | | [[Image:Austdiol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Avenaciolide.Mol]] | + | | Avenaciolide |
| + | | [[Image:Avenaciolide.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Averantin.Mol]] | + | | Averantin |
| + | | [[Image:Averantin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Avermectin_B1A.Mol]] | + | | Avermectin_B1A |
| + | | [[Image:Avermectin_B1A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Avermectin_B2A.Mol]] | + | | Avermectin_B2A |
| + | | [[Image:Avermectin_B2A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Averufin.Mol]] | + | | Averufin |
| + | | [[Image:Averufin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Avilamycin.Mol]] | + | | Avilamycin |
| + | | [[Image:Avilamycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Barnol.Mol]] | + | | Barnol |
| + | | [[Image:Barnol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Benzophenone.Mol]] | + | | Benzophenone |
| + | | [[Image:Benzophenone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Bikaverin.Mol]] | + | | Bikaverin |
| + | | [[Image:Bikaverin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Botryodiplodin.Mol]] | + | | Botryodiplodin |
| + | | [[Image:Botryodiplodin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Brefeldin_A.Mol]] | + | | Brefeldin_A |
| + | | [[Image:Brefeldin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Brevetoxin_A.Mol]] | + | | Brevetoxin_A |
| + | | [[Image:Brevetoxin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Brevetoxin_B.Mol]] | + | | Brevetoxin_B |
| + | | [[Image:Brevetoxin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:C-1027.Mol]] | + | | C-1027 |
| + | | [[Image:C-1027.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Calichemicin_Gamma1.Mol]] | + | | Calichemicin_Gamma1 |
| + | | [[Image:Calichemicin_Gamma1.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Cannabidiol.Mol]] | + | | Cannabidiol |
| + | | [[Image:Cannabidiol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Cannabigerolic_Acid.Mol]] | + | | Cannabigerolic_Acid |
| + | | [[Image:Cannabigerolic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Cannabinol.Mol]] | + | | Cannabinol |
| + | | [[Image:Cannabinol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Cercosporin.Mol]] | + | | Cercosporin |
| + | | [[Image:Cercosporin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Chlortetracycline.Mol]] | + | | Chlortetracycline |
| + | | [[Image:Chlortetracycline.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Chrysomycin_A.Mol]] | + | | Chrysomycin_A |
| + | | [[Image:Chrysomycin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Chrysomycin_B.Mol]] | + | | Chrysomycin_B |
| + | | [[Image:Chrysomycin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Chrysophanol.Mol]] | + | | Chrysophanol |
| + | | [[Image:Chrysophanol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Chrysophanol_Anthrone.Mol]] | + | | Chrysophanol_Anthrone |
| + | | [[Image:Chrysophanol_Anthrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ciguatoxin_I.Mol]] | + | | Ciguatoxin_I |
| + | | [[Image:Ciguatoxin_I.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Citreomontanin.Mol]] | + | | Citreomontanin |
| + | | [[Image:Citreomontanin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Citreoviridin.Mol]] | + | | Citreoviridin |
| + | | [[Image:Citreoviridin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Citrinin.Mol]] | + | | Citrinin |
| + | | [[Image:Citrinin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Clavatol.Mol]] | + | | Clavatol |
| + | | [[Image:Clavatol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Coarctatin.Mol]] | + | | Coarctatin |
| + | | [[Image:Coarctatin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Colletodiol.Mol]] | + | | Colletodiol |
| + | | [[Image:Colletodiol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Compactin.Mol]] | + | | Compactin |
| + | | [[Image:Compactin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Curvularin.Mol]] | + | | Curvularin |
| + | | [[Image:Curvularin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Deoxyherquienone.Mol]] | + | | Deoxyherquienone |
| + | | [[Image:Deoxyherquienone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Deoxyradicin.Mol]] | + | | Deoxyradicin |
| + | | [[Image:Deoxyradicin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Dihydroisocoumarin.Mol]] | + | | Dihydroisocoumarin |
| + | | [[Image:Dihydroisocoumarin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Diplosporin.Mol]] | + | | Diplosporin |
| + | | [[Image:Diplosporin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Discodermolide.Mol]] | + | | Discodermolide |
| + | | [[Image:Discodermolide.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Doramectin.Mol]] | + | | Doramectin |
| + | | [[Image:Doramectin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Dothistromin.Mol]] | + | | Dothistromin |
| + | | [[Image:Dothistromin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Doxorubicin.Mol]] | + | | Doxorubicin |
| + | | [[Image:Doxorubicin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Emodin.Mol]] | + | | Emodin |
| + | | [[Image:Emodin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Emodin_Anthrone.Mol]] | + | | Emodin_Anthrone |
| + | | [[Image:Emodin_Anthrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Emodin_Dianthrone.Mol]] | + | | Emodin_Dianthrone |
| + | | [[Image:Emodin_Dianthrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Endocrocin.Mol]] | + | | Endocrocin |
| + | | [[Image:Endocrocin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Endocrocin_Anthrone.Mol]] | + | | Endocrocin_Anthrone |
| + | | [[Image:Endocrocin_Anthrone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Enniatin_B.Mol]] | + | | Enniatin_B |
| + | | [[Image:Enniatin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Enterocin.Mol]] | + | | Enterocin |
| + | | [[Image:Enterocin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Epothilone_A.Mol]] | + | | Epothilone_A |
| + | | [[Image:Epothilone_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Epothilone_B.Mol]] | + | | Epothilone_B |
| + | | [[Image:Epothilone_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Epothilone_C.Mol]] | + | | Epothilone_C |
| + | | [[Image:Epothilone_C.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Epothilone_D.Mol]] | + | | Epothilone_D |
| + | | [[Image:Epothilone_D.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Epoxydon.Mol]] | + | | Epoxydon |
| + | | [[Image:Epoxydon.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Epsilon-Pyrromycinone.Mol]] | + | | Epsilon-Pyrromycinone |
| + | | [[Image:Epsilon-Pyrromycinone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Erythromycin.Mol]] | + | | Erythromycin |
| + | | [[Image:Erythromycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Flavipin.Mol]] | + | | Flavipin |
| + | | [[Image:Flavipin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Fumigatin.Mol]] | + | | Fumigatin |
| + | | [[Image:Fumigatin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Fumonisin_B1.Mol]] | + | | Fumonisin_B1 |
| + | | [[Image:Fumonisin_B1.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Furanomycin.Mol]] | + | | Furanomycin |
| + | | [[Image:Furanomycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Geldanamycin.Mol]] | + | | Geldanamycin |
| + | | [[Image:Geldanamycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Griseofulvin.Mol]] | + | | Griseofulvin |
| + | | [[Image:Griseofulvin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Griseophenone_B.Mol]] | + | | Griseophenone_B |
| + | | [[Image:Griseophenone_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Griseophenone_C.Mol]] | + | | Griseophenone_C |
| + | | [[Image:Griseophenone_C.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Humulone.Mol]] | + | | Humulone |
| + | | [[Image:Humulone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Hyperforin.Mol]] | + | | Hyperforin |
| + | | [[Image:Hyperforin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Hypericin.Mol]] | + | | Hypericin |
| + | | [[Image:Hypericin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Islandicin.Mol]] | + | | Islandicin |
| + | | [[Image:Islandicin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Isoepoxydon.Mol]] | + | | Isoepoxydon |
| + | | [[Image:Isoepoxydon.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Isousnic_Acid.Mol]] | + | | Isousnic_Acid |
| + | | [[Image:Isousnic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ivermectin.Mol]] | + | | Ivermectin |
| + | | [[Image:Ivermectin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Khellin.Mol]] | + | | Khellin |
| + | | [[Image:Khellin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Lasalocid.Mol]] | + | | Lasalocid |
| + | | [[Image:Lasalocid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Lecanoric_Acid.Mol]] | + | | Lecanoric_Acid |
| + | | [[Image:Lecanoric_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Leucomycin_A1.Mol]] | + | | Leucomycin_A1 |
| + | | [[Image:Leucomycin_A1.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ll-D253Alpha.Mol]] | + | | Ll-D253Alpha |
| + | | [[Image:Ll-D253Alpha.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Lovastatin.Mol]] | + | | Lovastatin |
| + | | [[Image:Lovastatin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:M-Cresol.Mol]] | + | | M-Cresol |
| + | | [[Image:M-Cresol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Melanin.Mol]] | + | | Melanin |
| + | | [[Image:Melanin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Mellein.Mol]] | + | | Mellein |
| + | | [[Image:Mellein.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Methylphloracetophenone.Mol]] | + | | Methylphloracetophenone |
| + | | [[Image:Methylphloracetophenone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Mollisin.Mol]] | + | | Mollisin |
| + | | [[Image:Mollisin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Monensin_A.Mol]] | + | | Monensin_A |
| + | | [[Image:Monensin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Multicolic_Acid.Mol]] | + | | Multicolic_Acid |
| + | | [[Image:Multicolic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Mycolactone.Mol]] | + | | Mycolactone |
| + | | [[Image:Mycolactone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Mycophenolic_Acid.Mol]] | + | | Mycophenolic_Acid |
| + | | [[Image:Mycophenolic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Myxalamide.Mol]] | + | | Myxalamide |
| + | | [[Image:Myxalamide.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Myxothiazol_Z.Mol]] | + | | Myxothiazol_Z |
| + | | [[Image:Myxothiazol_Z.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Niddamycin.Mol]] | + | | Niddamycin |
| + | | [[Image:Niddamycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Norsolorinic_Acid.Mol]] | + | | Norsolorinic_Acid |
| + | | [[Image:Norsolorinic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Nystatin.Mol]] | + | | Nystatin |
| + | | [[Image:Nystatin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ochratoxin_A.Mol]] | + | | Ochratoxin_A |
| + | | [[Image:Ochratoxin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ochrephilone.Mol]] | + | | Ochrephilone |
| + | | [[Image:Ochrephilone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Okadaic_Acid.Mol]] | + | | Okadaic_Acid |
| + | | [[Image:Okadaic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Oleandomycin.Mol]] | + | | Oleandomycin |
| + | | [[Image:Oleandomycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Olivetolic_Acid.Mol]] | + | | Olivetolic_Acid |
| + | | [[Image:Olivetolic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:O-Methylasparvenone.Mol]] | + | | O-Methylasparvenone |
| + | | [[Image:O-Methylasparvenone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Orcinol.Mol]] | + | | Orcinol |
| + | | [[Image:Orcinol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Orsellinic_Acid.Mol]] | + | | Orsellinic_Acid |
| + | | [[Image:Orsellinic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Oxytetracycline.Mol]] | + | | Oxytetracycline |
| + | | [[Image:Oxytetracycline.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Palitantin.Mol]] | + | | Palitantin |
| + | | [[Image:Palitantin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Patulin.Mol]] | + | | Patulin |
| + | | [[Image:Patulin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Penicillic_Acid.Mol]] | + | | Penicillic_Acid |
| + | | [[Image:Penicillic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Phloracetophenone.Mol]] | + | | Phloracetophenone |
| + | | [[Image:Phloracetophenone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Phlorisobutyrophenone.Mol]] | + | | Phlorisobutyrophenone |
| + | | [[Image:Phlorisobutyrophenone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Phlorisovalerophenone.Mol]] | + | | Phlorisovalerophenone |
| + | | [[Image:Phlorisovalerophenone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Physcion.Mol]] | + | | Physcion |
| + | | [[Image:Physcion.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Picromycin.Mol]] | + | | Picromycin |
| + | | [[Image:Picromycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Pimaricin.Mol]] | + | | Pimaricin |
| + | | [[Image:Pimaricin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Pretetramide.Mol]] | + | | Pretetramide |
| + | | [[Image:Pretetramide.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Protohypericin.Mol]] | + | | Protohypericin |
| + | | [[Image:Protohypericin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Pyochelin.Mol]] | + | | Pyochelin |
| + | | [[Image:Pyochelin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Pyoluteorin.Mol]] | + | | Pyoluteorin |
| + | | [[Image:Pyoluteorin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Radicin.Mol]] | + | | Radicin |
| + | | [[Image:Radicin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rapamycin.Mol]] | + | | Rapamycin |
| + | | [[Image:Rapamycin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Ravenilin.Mol]] | + | | Ravenilin |
| + | | [[Image:Ravenilin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rhein.Mol]] | + | | Rhein |
| + | | [[Image:Rhein.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rifabutin.Mol]] | + | | Rifabutin |
| + | | [[Image:Rifabutin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rifamycin_B.Mol]] | + | | Rifamycin_B |
| + | | [[Image:Rifamycin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rifapentine.Mol]] | + | | Rifapentine |
| + | | [[Image:Rifapentine.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rosellisin.Mol]] | + | | Rosellisin |
| + | | [[Image:Rosellisin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rubrofusarin.Mol]] | + | | Rubrofusarin |
| + | | [[Image:Rubrofusarin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Rubropunctatin.Mol]] | + | | Rubropunctatin |
| + | | [[Image:Rubropunctatin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sclerin.Mol]] | + | | Sclerin |
| + | | [[Image:Sclerin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sclerotinin_A.Mol]] | + | | Sclerotinin_A |
| + | | [[Image:Sclerotinin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sek4.Mol]] | + | | Sek4 |
| + | | [[Image:Sek4.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sek4B.Mol]] | + | | Sek4B |
| + | | [[Image:Sek4B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Selamectin.Mol]] | + | | Selamectin |
| + | | [[Image:Selamectin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennidin_A.Mol]] | + | | Sennidin_A |
| + | | [[Image:Sennidin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennidin_B.Mol]] | + | | Sennidin_B |
| + | | [[Image:Sennidin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennidin_C.Mol]] | + | | Sennidin_C |
| + | | [[Image:Sennidin_C.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennidin_D.Mol]] | + | | Sennidin_D |
| + | | [[Image:Sennidin_D.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennosides_A.Mol]] | + | | Sennosides_A |
| + | | [[Image:Sennosides_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennosides_B.Mol]] | + | | Sennosides_B |
| + | | [[Image:Sennosides_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennosides_C.Mol]] | + | | Sennosides_C |
| + | | [[Image:Sennosides_C.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sennosides_D.Mol]] | + | | Sennosides_D |
| + | | [[Image:Sennosides_D.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sepedonin.Mol]] | + | | Sepedonin |
| + | | [[Image:Sepedonin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Siccanin.Mol]] | + | | Siccanin |
| + | | [[Image:Siccanin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Silvaticamide.Mol]] | + | | Silvaticamide |
| + | | [[Image:Silvaticamide.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sma76A.Mol]] | + | | Sma76A |
| + | | [[Image:Sma76A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sma76B.Mol]] | + | | Sma76B |
| + | | [[Image:Sma76B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sma76C.Mol]] | + | | Sma76C |
| + | | [[Image:Sma76C.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Soraphen_A.Mol]] | + | | Soraphen_A |
| + | | [[Image:Soraphen_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Spinulosin.Mol]] | + | | Spinulosin |
| + | | [[Image:Spinulosin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Spiramycin_I.Mol]] | + | | Spiramycin_I |
| + | | [[Image:Spiramycin_I.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sterigmatocystin.Mol]] | + | | Sterigmatocystin |
| + | | [[Image:Sterigmatocystin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Stigmatellin_A.Mol]] | + | | Stigmatellin_A |
| + | | [[Image:Stigmatellin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Stipitatonic_Acid.Mol]] | + | | Stipitatonic_Acid |
| + | | [[Image:Stipitatonic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Sulochrin.Mol]] | + | | Sulochrin |
| + | | [[Image:Sulochrin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tacrolimus.Mol]] | + | | Tacrolimus |
| + | | [[Image:Tacrolimus.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tajixanthone.Mol]] | + | | Tajixanthone |
| + | | [[Image:Tajixanthone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tennellin.Mol]] | + | | Tennellin |
| + | | [[Image:Tennellin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Terrein.Mol]] | + | | Terrein |
| + | | [[Image:Terrein.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Terrequinone_A.Mol]] | + | | Terrequinone_A |
| + | | [[Image:Terrequinone_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tetracenomycin_F2.Mol]] | + | | Tetracenomycin_F2 |
| + | | [[Image:Tetracenomycin_F2.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tetracycline.Mol]] | + | | Tetracycline |
| + | | [[Image:Tetracycline.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tetrahydro_Cannabinol.Mol]] | + | | Tetrahydro_Cannabinol |
| + | | [[Image:Tetrahydro_Cannabinol.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tetrahydroxynaphthalene.Mol]] | + | | Tetrahydroxynaphthalene |
| + | | [[Image:Tetrahydroxynaphthalene.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Triacetic_Acid_Lactone.Mol]] | + | | Triacetic_Acid_Lactone |
| + | | [[Image:Triacetic_Acid_Lactone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:T-Toxin.Mol]] | + | | T-Toxin |
| + | | [[Image:T-Toxin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tylactone.Mol]] | + | | Tylactone |
| + | | [[Image:Tylactone.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Tylosin.Mol]] | + | | Tylosin |
| + | | [[Image:Tylosin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Urushiol_III.Mol]] | + | | Urushiol_III |
| + | | [[Image:Urushiol_III.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Usnic_Acid.Mol]] | + | | Usnic_Acid |
| + | | [[Image:Usnic_Acid.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Variotin.Mol]] | + | | Variotin |
| + | | [[Image:Variotin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Versicolorin_A.Mol]] | + | | Versicolorin_A |
| + | | [[Image:Versicolorin_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Versicolorin_B.Mol]] | + | | Versicolorin_B |
| + | | [[Image:Versicolorin_B.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Versiconal.Mol]] | + | | Versiconal |
| + | | [[Image:Versiconal.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Versiconal_Acetate.Mol]] | + | | Versiconal_Acetate |
| + | | [[Image:Versiconal_Acetate.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Visnagin.Mol]] | + | | Visnagin |
| + | | [[Image:Visnagin.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Wa-Naphthopyron.Mol]] | + | | Wa-Naphthopyron |
| + | | [[Image:Wa-Naphthopyron.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Zaragozic_Acids_A.Mol]] | + | | Zaragozic_Acids_A |
| + | | [[Image:Zaragozic_Acids_A.Mol.png]] | ||
|- | |- | ||
| − | | [[Image:Zearalenone.Mol]] | + | | Zearalenone |
| + | | [[Image:Zearalenone.Mol.png]] | ||
|} | |} | ||
Revision as of 12:32, 6 March 2010
Polyketide (ポリケチド)
Contents |
Class Overview
Polyketides are synthesized through the polymerization of acetyl units (β-ketomethylene chain).
| 1st Class | ||
|---|---|---|
| PK4: Four C2 Units orsellinic acid, 6-methylsalicylic acid, triacetic acid lactone, asperlin, usnic acid, methylphloracetophenone, penicillic acid, patulin |
PK5: Five C2 Units citrinin, aflatoxin, augenone, sepedonin, stipitatonic acid |
PK6: Six C2 Units plumbagin, 7-methyljuglone, juglone, variotin |
| PK7: Seven and eight C2 Units Anthraquinone rings |
PK9: Nine C2 Units Tetracyclines | |
Polyketide Synthase (PKS)
| species | Actinomycetes | Cyanobacteria | γ-Proteobacteria | Fungi | Dinoflagellates |
|---|---|---|---|---|---|
| Type-I PKS | Ο | Ο | Ο | Χ | Ο |
| Type-II PKS | Ο | Χ | Χ | Ο | Χ |
| NRPS | Ο | Ο | Ο | Ο | Χ |
| deoxysugar | Ο | Χ | Χ | Χ | Χ |
| Terpene | Δ | Χ | Χ | Ο | Χ |
Type I PKS (non-iterative)
- Multi catalytic domains exist in a single protein
- Chain length is determined by the number of catalytic domains.
- Products are non-aromatic and have larger masses.
Ref. Erythromycin biosynthesis in Nat Prod Rep 18, 380 (2001)
Type II PKS (iterative)
- Three proteins (KSα, KSβ, ACP) are repeatedly used for carbon chain elongation.
- Chain length is determined by another protein, CLF.
- In bacteria, products are aromatic (e.g. chiorotetracycline, pradimicin).
- In fungi, products are both non-aromatic and aromatic.
Non-ribosomal peptide synthase (NRPS)
Coupling with PKS and NRPS
- vancomycin ()
- leinamycin (Curr opin chem biol 7:285, 2003)
- pseurotin (chem bio chem 8:1736-1743, 2007)
- curacin (curr opin chem biol 13:216, 2009)
- epothilone
- rapamycin
PKS in Fungi
- both aromatic and non-aromatic compounds are generated by iterative PKS
- methyl branch is transferred from methionine, not methylmalonyl CoA
Ref. Dewick, PM Medicinal Natural Products (2009)
Decoration
deoxysugars
deoxygenation, c-methylation, amination, n-methylation, ketosugar,
Unusual structures
| Phoma | zaragozic acid, phomoidoride | Streptomyces | yatakemycin, leinamycin, saframycin, neocarzinostatin, staurosporin, FR182877 | Other bacteria | PKS-NRPS hybrid type
Curacin A (Lyngbya), Shiphonazole (Herpetosiphon), Jamaicamide A (Lyngbya), Cylindrospermopsin (Cylindrospermopsis) |
|---|
| 1,3,8-Trihydroxyaceto-Naphthalene | 
|
| 1,3-Dihydroxy-N-Methylacridone | 
|
| 3,8-Dihydroxy-1-Methylanthraquinone-2-Carboxylic_Acid | 
|
| 4-Hydroxy-2-Quinolone | 
|
| 5,7-Dihydroxy-2-Methylchromone | 
|
| 5-Methylorsellinic_Acid | 
|
| 6-Deoxy-Erythronolide_B | 
|
| 6-Methoxymellein | 
|
| 6-Methyl_Salicylic_Acid | 
|
| Actinorhodin | 
|
| Adhyperforin | 
|
| Aflatoxin_B1 | 
|
| Aflatoxin_B2 | 
|
| Aflatoxin_G1 | 
|
| Aflatoxin_G2 | 
|
| Aflatoxin_M1 | 
|
| Aloe-Emodin | 
|
| Aloesaponarin_II | 
|
| Alternapyrone | 
|
| Alternaric_Acid | 
|
| Alternariol | 
|
| Amphotericin_B | 
|
| Andrimid_ | 
|
| Ascomycin | 
|
| Aslaniol | 
|
| Aslanipyrone | 
|
| Asperlactone | 
|
| Asperlin | 
|
| Aspyridone_A | 
|
| Aspyridone_B | 
|
| Aspyrone | 
|
| Asteltoxin | 
|
| Astepyrone | 
|
| Atrochrysone | 
|
| Atrochrysone_Carboxylic_Acid | 
|
| Aureothin | 
|
| Austdiol | 
|
| Avenaciolide | 
|
| Averantin | 
|
| Avermectin_B1A | 
|
| Avermectin_B2A | 
|
| Averufin | 
|
| Avilamycin | 
|
| Barnol | 
|
| Benzophenone | 
|
| Bikaverin | 
|
| Botryodiplodin | 
|
| Brefeldin_A | 
|
| Brevetoxin_A | 
|
| Brevetoxin_B | 
|
| C-1027 | 
|
| Calichemicin_Gamma1 | 
|
| Cannabidiol | 
|
| Cannabigerolic_Acid | 
|
| Cannabinol | 
|
| Cercosporin | 
|
| Chlortetracycline | 
|
| Chrysomycin_A | 
|
| Chrysomycin_B | 
|
| Chrysophanol | 
|
| Chrysophanol_Anthrone | 
|
| Ciguatoxin_I | 
|
| Citreomontanin | 
|
| Citreoviridin | 
|
| Citrinin | 
|
| Clavatol | 
|
| Coarctatin | 
|
| Colletodiol | 
|
| Compactin | 
|
| Curvularin | 
|
| Deoxyherquienone | 
|
| Deoxyradicin | 
|
| Dihydroisocoumarin | 
|
| Diplosporin | 
|
| Discodermolide | 
|
| Doramectin | 
|
| Dothistromin | 
|
| Doxorubicin | 
|
| Emodin | 
|
| Emodin_Anthrone | 
|
| Emodin_Dianthrone | 
|
| Endocrocin | 
|
| Endocrocin_Anthrone | 
|
| Enniatin_B | 
|
| Enterocin | 
|
| Epothilone_A | 
|
| Epothilone_B | 
|
| Epothilone_C | 
|
| Epothilone_D | 
|
| Epoxydon | 
|
| Epsilon-Pyrromycinone | 
|
| Erythromycin | 
|
| Flavipin | 
|
| Fumigatin | 
|
| Fumonisin_B1 | 
|
| Furanomycin | 
|
| Geldanamycin | 
|
| Griseofulvin | 
|
| Griseophenone_B | 
|
| Griseophenone_C | 
|
| Humulone | 
|
| Hyperforin | 
|
| Hypericin | 
|
| Islandicin | 
|
| Isoepoxydon | 
|
| Isousnic_Acid | 
|
| Ivermectin | 
|
| Khellin | 
|
| Lasalocid | 
|
| Lecanoric_Acid | 
|
| Leucomycin_A1 | 
|
| Ll-D253Alpha | 
|
| Lovastatin | 
|
| M-Cresol | 
|
| Melanin | 
|
| Mellein | 
|
| Methylphloracetophenone | 
|
| Mollisin | 
|
| Monensin_A | 
|
| Multicolic_Acid | 
|
| Mycolactone | 
|
| Mycophenolic_Acid | 
|
| Myxalamide | 
|
| Myxothiazol_Z | 
|
| Niddamycin | 
|
| Norsolorinic_Acid | 
|
| Nystatin | 
|
| Ochratoxin_A | 
|
| Ochrephilone | 
|
| Okadaic_Acid | 
|
| Oleandomycin | 
|
| Olivetolic_Acid | 
|
| O-Methylasparvenone | 
|
| Orcinol | 
|
| Orsellinic_Acid | 
|
| Oxytetracycline | 
|
| Palitantin | 
|
| Patulin | 
|
| Penicillic_Acid | 
|
| Phloracetophenone | 
|
| Phlorisobutyrophenone | 
|
| Phlorisovalerophenone | 
|
| Physcion | 
|
| Picromycin | 
|
| Pimaricin | 
|
| Pretetramide | 
|
| Protohypericin | 
|
| Pyochelin | 
|
| Pyoluteorin | 
|
| Radicin | 
|
| Rapamycin | 
|
| Ravenilin | 
|
| Rhein | 
|
| Rifabutin | 
|
| Rifamycin_B | 
|
| Rifapentine | 
|
| Rosellisin | 
|
| Rubrofusarin | 
|
| Rubropunctatin | 
|
| Sclerin | 
|
| Sclerotinin_A | 
|
| Sek4 | 
|
| Sek4B | 
|
| Selamectin | 
|
| Sennidin_A | 
|
| Sennidin_B | 
|
| Sennidin_C | 
|
| Sennidin_D | 
|
| Sennosides_A | 
|
| Sennosides_B | 
|
| Sennosides_C | 
|
| Sennosides_D | 
|
| Sepedonin | 
|
| Siccanin | 
|
| Silvaticamide | 
|
| Sma76A | 
|
| Sma76B | 
|
| Sma76C | 
|
| Soraphen_A | 
|
| Spinulosin | 
|
| Spiramycin_I | 
|
| Sterigmatocystin | 
|
| Stigmatellin_A | 
|
| Stipitatonic_Acid | 
|
| Sulochrin | 
|
| Tacrolimus | 
|
| Tajixanthone | 
|
| Tennellin | 
|
| Terrein | 
|
| Terrequinone_A | 
|
| Tetracenomycin_F2 | 
|
| Tetracycline | 
|
| Tetrahydro_Cannabinol | 
|
| Tetrahydroxynaphthalene | 
|
| Triacetic_Acid_Lactone | 
|
| T-Toxin | 
|
| Tylactone | 
|
| Tylosin | 
|
| Urushiol_III | 
|
| Usnic_Acid | 
|
| Variotin | 
|
| Versicolorin_A | 
|
| Versicolorin_B | 
|
| Versiconal | 
|
| Versiconal_Acetate | 
|
| Visnagin | 
|
| Wa-Naphthopyron | 
|
| Zaragozic_Acids_A | 
|
| Zearalenone | 
|
