Category:Floratheasaponin

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(New page: {{Twocolumn| Floratheasaponin A-C is known to significantly reduce the amount of neutral lipids (triglycerides) in blood serum for 50-100 mg/kg<ref>Yoshikawa M, Morikawa T, Yamamoto K, Kat...)
 
 
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Floratheasaponin A-C is known to significantly reduce the amount of neutral lipids (triglycerides) in blood serum for 50-100 mg/kg<ref>Yoshikawa M, Morikawa T, Yamamoto K, Kato Y, Nagatomo A, Matsuda H (2005) ''J Nat Prod'' 68:1360-1365</ref>.  For this activity, acylation at 21 and 22 positions of the triterpene structure is necessary. Chakasaponin I-III inhibits pancreatic lipase and for this activity, the hydroxyl group at position 15 is important.  Other functionality of floral saponins are anti-allergy and gastric mucosal protection <ref>Yoshikawa M, Wang T, Sugimoto S, Nakamura S, Nagatomo A, Matsuda H, Harima S (2008) ''Yakugaku Zasshi'' 128:141-151</ref>.
 
Floratheasaponin A-C is known to significantly reduce the amount of neutral lipids (triglycerides) in blood serum for 50-100 mg/kg<ref>Yoshikawa M, Morikawa T, Yamamoto K, Kato Y, Nagatomo A, Matsuda H (2005) ''J Nat Prod'' 68:1360-1365</ref>.  For this activity, acylation at 21 and 22 positions of the triterpene structure is necessary. Chakasaponin I-III inhibits pancreatic lipase and for this activity, the hydroxyl group at position 15 is important.  Other functionality of floral saponins are anti-allergy and gastric mucosal protection <ref>Yoshikawa M, Wang T, Sugimoto S, Nakamura S, Nagatomo A, Matsuda H, Harima S (2008) ''Yakugaku Zasshi'' 128:141-151</ref>.
 
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Floratheasaponin A-C は50-100 mg/kg の用量なら、血中の中性脂質（トリグリセリド）を有意に抑制します<ref>Yoshikawa M, Morikawa T, Yamamoto K, Kato Y, Nagatomo A, Matsuda H (2005) ''J Nat Prod'' 68:1360-1365</ref>。この活性には、トリテルペン部の21,22位に結合したアシル基が必須です。またchakasaponin I-IIIは膵リパーゼ阻害作用を持ち、これには15位水酸基の存在が重要です。その他、抗アレルギー、胃粘膜保護作用<ref>Yoshikawa M, Wang T, Sugimoto S, Nakamura S, Nagatomo A, Matsuda H, Harima S (2008) ''Yakugaku Zasshi'' 128:141-151</ref>等も見出されています。
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Floratheasaponin A-C は50-100 mg/kg の用量なら、血中の中性脂質（トリグリセリド）を有意に抑制します。
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この活性には、トリテルペン部の21,22位に結合したアシル基が必須です。
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またchakasaponin I-IIIは膵リパーゼ阻害作用を持ち、これには15位水酸基の存在が重要です。
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その他、抗アレルギー、胃粘膜保護作用等も見出されています。
 
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<references/>
 
* Yoshikawa M, Nakamura S, Kato Y, Matsuhira K, Matsuda H (2007) ''Chem Pharm Bull'' 55:598-605
 
* Yoshikawa M, Nakamura S, Kato Y, Matsuhira K, Matsuda H (2007) ''Chem Pharm Bull'' 55:598-605
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*
 
 
* Yoshikawa M, Sugimoto S, Nakamura S, Matsuda H (2008) ''Chem Pharm Bull'' 56:1297-1303
 
* Yoshikawa M, Sugimoto S, Nakamura S, Matsuda H (2008) ''Chem Pharm Bull'' 56:1297-1303
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* Yoshikawa M, Sugimoto S, Kato Y, Nakamura S, Wang T, Yamashita C, Matsuda H (2008)??
 
  
 
===Floratheasaponins===
 
===Floratheasaponins===

Latest revision as of 15:08, 17 August 2010

Floratheasaponin A-C is known to significantly reduce the amount of neutral lipids (triglycerides) in blood serum for 50-100 mg/kg[1]. For this activity, acylation at 21 and 22 positions of the triterpene structure is necessary. Chakasaponin I-III inhibits pancreatic lipase and for this activity, the hydroxyl group at position 15 is important. Other functionality of floral saponins are anti-allergy and gastric mucosal protection [2].

  1. ↑ Yoshikawa M, Morikawa T, Yamamoto K, Kato Y, Nagatomo A, Matsuda H (2005) J Nat Prod 68:1360-1365
  2. ↑ Yoshikawa M, Wang T, Sugimoto S, Nakamura S, Nagatomo A, Matsuda H, Harima S (2008) Yakugaku Zasshi 128:141-151
  • Yoshikawa M, Nakamura S, Kato Y, Matsuhira K, Matsuda H (2007) Chem Pharm Bull 55:598-605
  • Yoshikawa M, Sugimoto S, Nakamura S, Matsuda H (2008) Chem Pharm Bull 56:1297-1303

[edit] Floratheasaponins

Name R1 R2 R3 R4 R5 R6
Floratheasaponin A H H Ang Ac H Xyl
Floratheasaponin B OH H Ang Ang H Xyl
Floratheasaponin C OH H Ang 2MB H Xyl
Floratheasaponin D H H Ang Ac H Rha
Floratheasaponin E OH H Ang Ang H Rha
Floratheasaponin F OH H Ang 2MB H Rha
Floratheasaponin G H H Tig Ac H Rha
Floratheasaponin H H Ac Ang Ac H Rha
Floratheasaponin I H H Ang H Ac Rha
Chakasaponin I H H Tig Ac H Xyl
Chakasaponin II OH H Tig Tig H Xyl
Chakasaponin III OH H Tig Ac H Xyl

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