Enzyme:6.3.2.12

Revision as of 09:00, 2 February 2009

dihydropteroate:L-glutamate ligase (ADP-forming)
Systematic Name	dihydropteroate:L-glutamate ligase (ADP-forming)
Common Name	dihydrofolate synthase dihydrofolate synthetase 7,8-dihydrofolate synthetase H2-folate synthetase 7,8-dihydropteroate:L-glutamate ligase (ADP)

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0020$0	ADP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

10-Formyl-tetrahydro-folic acid	<Mapping> AtomMap:BMCCPTFOo001$BMCCPTFOo002$0	2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 15 15 ↔ 20 16 ↔ 19 17 ↔ 18 18 ↔ 17 19 ↔ 16 20 ↔ 21 21 ↔ 22 22 ↔ 23 23 ↔ 24 24 ↔ 25 25 ↔ 26 26 ↔ 27 27 ↔ 14

(2S) -2-Amino-pentanedioic acid	<Mapping> AtomMap:BMAAS5CA0007$BMCCPTFOo002$0	2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid
	1 ↔ 28 2 ↔ 29 3 ↔ 30 4 ↔ 31 5 ↔ 32 6 ↔ 33

ATP + 7,8-Dihydro-pteroic acid + L-Glutamic acid => ADP + 7,8-Dihydro-folic acid + Orthophosphate
(links: ATP + 7,8-Dihydro-pteroic acid + (2S) -2-Amino-pentanedioic acid = ADP + 7,8-Dihydro-folic acid)

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0020$0	ADP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

7,8-Dihydro-pteroic acid	<Mapping> AtomMap:BMCCPTPTk014$BMCCPTFO0011$0	7,8-Dihydro-folic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 19 16 ↔ 18 17 ↔ 17 18 ↔ 16 19 ↔ 15 20 ↔ 20

(2S) -2-Amino-pentanedioic acid	<Mapping> AtomMap:BMAAS5CA0007$BMCCPTFO0011$0	7,8-Dihydro-folic acid
	1 ↔ 22 2 ↔ 23 3 ↔ 24 4 ↔ 25 5 ↔ 26 6 ↔ 21

@@ Line 3: / Line 3: @@
 |SysName=dihydropteroate:L-glutamate ligase (ADP-forming)
 |names=&&dihydrofolate synthase&&dihydrofolate synthetase&&7,8-dihydrofolate synthetase&&H2-folate synthetase&&7,8-dihydropteroate:L-glutamate ligase (ADP)
+}}
+{{Enzyme/Reaction| reaction= ATP + 10-Formyl-tetrahydro-folic acid + L-Glutamic acid => ADP + 10-Formyl-THF-L-glutamic acid + Orthophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0020$0
+&& BMCCPTFOo001$BMCCPTFOo002$0
+&& BMAAS5CA0007$BMCCPTFOo002$0
+}}
+{{Enzyme/Reaction| reaction= ATP + 7,8-Dihydro-pteroic acid + L-Glutamic acid => ADP + 7,8-Dihydro-folic acid + Orthophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0020$0
+&& BMCCPTPTk014$BMCCPTFO0011$0
+&& BMAAS5CA0007$BMCCPTFO0011$0
 }}

IDs and Links
IUBMB	EC6
ExPaSy	NiceZyme 6.3.2.12