Enzyme:2.1.1.6

Revision as of 09:00, 2 February 2009

S-adenosyl-L-methionine:catechol O-methyltransferase
Systematic Name	S-adenosyl-L-methionine:catechol O-methyltransferase
Common Name	catechol O-methyltransferase COMT I COMT II S-COMT (soluble form of catechol-O-methyltransferase) MB-COMT (membrane-bound form of catechol-O-methyltransferase)

S-Adenosyl-L-methionine	<Mapping> AtomMap:BMCCPUADf014$BMCCPUADf012$0	S-Adenosyl-L-homocysteine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10 12 ↔ 11 13 ↔ 12 14 ↔ 13 15 ↔ 14 16 ↔ 15 17 ↔ 16 18 ↔ 17 19 ↔ 18 20 ↔ 19 21 ↔ 20 22 ↔ 21

4- [1R-1-Hydroxy-2-(methylamino)ethyl] -1,2-benzenediol	<Mapping> AtomMap:BMMCBZ3Sm054$BMMCBZ3Sm055$0	4- [1-Hydroxy-2- (methylamino) ethyl] -2-methoxyphenol
	1 ↔ 4 2 ↔ 3 3 ↔ 2 4 ↔ 1 5 ↔ 6 6 ↔ 5 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10

S-Adenosyl-L-methionine	<Mapping> AtomMap:BMCCPUADf014$BMMCBZ3Sm055$0	4- [1-Hydroxy-2- (methylamino) ethyl] -2-methoxyphenol
	7 ↔ 12

S-Adenosyl-L-methionine + L-Noradrenaline = S-Adenosyl-L-homocysteine + L-Normetanephrine
(links: S-Adenosyl-L-methionine + L-Noradrenaline = S-Adenosyl-L-homocysteine + 4- (2-Amino-1-hydroxyethyl) -2-methoxyphenol)

S-Adenosyl-L-methionine	<Mapping> AtomMap:BMCCPUADf014$BMCCPUADf012$0	S-Adenosyl-L-homocysteine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10 12 ↔ 11 13 ↔ 12 14 ↔ 13 15 ↔ 14 16 ↔ 15 17 ↔ 16 18 ↔ 17 19 ↔ 18 20 ↔ 19 21 ↔ 20 22 ↔ 21

L-Noradrenaline	<Mapping> AtomMap:BMMCBZ3Sm056$BMMCBZ3Sm057$0	4- (2-Amino-1-hydroxyethyl) -2-methoxyphenol
	1 ↔ 4 2 ↔ 3 3 ↔ 2 4 ↔ 1 5 ↔ 6 6 ↔ 5 7 ↔ 7 8 ↔ 8 9 ↔ 9

S-Adenosyl-L-methionine	<Mapping> AtomMap:BMCCPUADf014$BMMCBZ3Sm057$0	4- (2-Amino-1-hydroxyethyl) -2-methoxyphenol
	7 ↔ 11

S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid = S-Adenosyl-L-homocysteine + Homovanillic acid
(links: S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid = S-Adenosyl-L-homocysteine + 2- (4-Hydroxy-3-methoxyphenyl) acetic acid)

S-Adenosyl-L-methionine	<Mapping> AtomMap:BMCCPUADf014$BMCCPUADf012$0	S-Adenosyl-L-homocysteine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 10 12 ↔ 11 13 ↔ 12 14 ↔ 13 15 ↔ 14 16 ↔ 15 17 ↔ 16 18 ↔ 17 19 ↔ 18 20 ↔ 19 21 ↔ 20 22 ↔ 21

3,4-Dihydroxy-phenyl-acetic acid	<Mapping> AtomMap:BMMCBZ3Sk020$BMMCBZ3Sk053$0	2- (4-Hydroxy-3-methoxyphenyl) acetic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8

S-Adenosyl-L-methionine	<Mapping> AtomMap:BMCCPUADf014$BMMCBZ3Sk053$0	2- (4-Hydroxy-3-methoxyphenyl) acetic acid
	7 ↔ 12

@@ Line 3: / Line 3: @@
 |SysName=S-adenosyl-L-methionine:catechol O-methyltransferase
 |names=&&catechol O-methyltransferase&&COMT I&&COMT II&&S-COMT (soluble form of catechol-O-methyltransferase)&&MB-COMT (membrane-bound form of catechol-O-methyltransferase)
+}}
+{{Enzyme/Reaction| reaction= S-Adenosyl-L-methionine + L-Adrenaline = S-Adenosyl-L-homocysteine + L-Metanephrine
+| list=
+&& BMCCPUADf014$BMCCPUADf012$0
+&& BMMCBZ3Sm054$BMMCBZ3Sm055$0
+&& BMCCPUADf014$BMMCBZ3Sm055$0
+}}
+{{Enzyme/Reaction| reaction= S-Adenosyl-L-methionine + L-Noradrenaline = S-Adenosyl-L-homocysteine + L-Normetanephrine
+| list=
+&& BMCCPUADf014$BMCCPUADf012$0
+&& BMMCBZ3Sm056$BMMCBZ3Sm057$0
+&& BMCCPUADf014$BMMCBZ3Sm057$0
+}}
+{{Enzyme/Reaction| reaction= S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid = S-Adenosyl-L-homocysteine + Homovanillic acid
+| list=
+&& BMCCPUADf014$BMCCPUADf012$0
+&& BMMCBZ3Sk020$BMMCBZ3Sk053$0
+&& BMCCPUADf014$BMMCBZ3Sk053$0
 }}

IDs and Links
IUBMB	EC2
ExPaSy	NiceZyme 2.1.1.6