Enzyme:1.2.4.4

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Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.2.-.- Acting on the aldehyde or oxo group of donors. : EC1.2.4.- With a disulfide as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.4.4

3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-2-methylpropanoylating)
Systematic Name	3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-2-methylpropanoylating)
Common Name	3-methyl-2-oxobutanoate dehydrogenase(2-methylpropanoyl-transferring) 2-oxoisocaproate dehydrogenase 2-oxoisovalerate (lipoate) dehydrogenase 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylatingand acceptor-2-methylpropanoylating)

TPP + 3-Methyl-2-oxo-butanoic acid => 2-(2-Methyl-propanoyl)-thiamine diphosphate + CO2
(links: TPP + 3-Methyl-2-oxo-butanoic acid = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate + CO2)

TPP + 4-Methyl-2-oxo-pentanoic acid => 2-(3-Methyl-butanoyl)-thiamine diphosphate + CO2
(links: TPP + 4-Methyl-2-oxo-pentanoic acid = 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen + CO2)

2-(3-Methyl-butanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(3-Methyl-butanoyl)-dihydro-lipoamide
(links: 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-3-methylbutyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen + Lipoamide = TPP + S- (8-Amino-8-oxo-3-sulfanyloctyl) 3-methylbutanethioic acid)

2-((2S)-2-Methyl-butanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(2-Methyl-butanoyl)-dihydro-lipoamide
(links: 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- [(2S) -1-hydroxy-2-methylbutyl] -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate + Lipoamide = TPP + S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylbutanethioic acid)

2-(2-Methyl-propanoyl)-thiamine diphosphate + Lipoamide => TPP + S-(2-Methyl-propanoyl)-dihydro-lipoamide
(links: 2- [3- [(4-Amino-2-methylpyrimidin-5-yl) methyl] -2- (1-hydroxy-2-methylpropyl) -4-methyl-1,3-thiazol-3-ium-5-yl] ethyl phosphono hydrogen phosphate + Lipoamide = TPP + S- (8-Amino-8-oxo-3-sulfanyloctyl) 2-methylpropanethioic acid)

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