Doc:Tea/Health - Revision history

Adm at 06:54, 22 September 2010

2010-09-22T06:54:41Z

Adm at 06:57, 17 August 2010

2010-08-17T06:57:01Z

Adm: /* Cardiovascular Disease (CVD) 循環器疾患 */

2010-07-02T05:49:02Z

‎Cardiovascular Disease (CVD) 循環器疾患

Adm: /* Cancer 癌 */

2010-07-02T05:47:32Z

‎Cancer 癌

Adm: /* Cardiovascular Disease (CVD) 循環器疾患 */

2010-07-02T05:40:05Z

‎Cardiovascular Disease (CVD) 循環器疾患

Adm at 15:48, 26 February 2010

2010-02-26T15:48:12Z

Adm at 08:53, 25 February 2010

2010-02-25T08:53:14Z

Adm: New page: ==Tea and Human Health (健康情報)== ===Cancer 癌=== {{Twocolumn|As below, none of the large-scale epidemiological studies showed a significant association of tea intak...

2010-02-25T07:58:46Z

New page: ==Tea and Human Health (健康情報)== ===Cancer 癌=== {{Twocolumn|As below, none of the large-scale epidemiological studies showed a significant association of tea intak...

New page

==Tea and Human Health (健康情報)==

===Cancer 癌===
{{Twocolumn|As below, none of the large-scale epidemiological studies showed a significant association of tea intake with a lower risk of cancer<ref name="Borrelli">Borrelli F, Capasso R et al. (2004) "Systematic review: green tea and gastrointestinal cancer risk" Aliment Pharmacol Ther 19:497-510</ref>. However, many case-control studies and cross-sectional studies (up to several hundreds people) show a decrease of the risk of cancer.
|
以下のように、いずれの大規模疫学調査においても、お茶を飲む習慣と低い癌リスクの関連は見出されていません<ref name="Borrelli"/>。ただし、多くの症例コントロール研究や横断的研究で癌リスクの低下は報告されています。 
}}
* Breast cancer 乳がん
:: Two prospective studies with 35,004 women <ref>Suzuki Y, Tsubono Y et al. (2004) "Gren tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan" Br J Cancer 90:1361-1363</ref> → no association
* Gastrointestinal cancer 胃腸がん
:: Prospective cohort 14873 men and 23667 women <ref name="Nagano">Nagano J, Kono S et al. (2001) "A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan)" Cancer Causes Control 12:501-508</ref> → no association
:: Prospective cohort 11902 men and 14409 women <ref>Tsubono Y, Nishino Y et al. (2001) "Green tea and the risk of gastric cancer in Japan" New Engl J Med 344:632-636</ref> → no association
:: Prospective cohort 30370 men and 42481 women <ref>Hoshiyama Y, Kawaguchi T et al. (2002) "A prospective study of stomach cancer death in relation to green tea consumption in Japan" Br J Cancer 87:309-313</ref> → no association
:: Prospective cohort 18746 men and 26184 women <ref>Fujino Y, tamakoshi A et al. (2002) "Prospective study of education background and stomach cancer in Japan" Prev Med 35:121-127</ref> → no association
* Bladder cancer 膀胱がん
:: Prospective cohort 14873 men and 23667 women <ref name="Nagano"/> → no association
* Cancer incidence がん
:: Prospective study 38540 people <ref name="Nagano"/> → no association

;References
<references/>

===Cardiovascular Disease (CVD) 循環器疾患===
{{Twocolumn|
It is often believed that (oolong) tea possesses hypotensive effects.
After Hertog MG et al.<ref name="Hertog">Hertog MG, Feskens EJ (1993) "Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study" Lancet 342(8878):1007-1011</ref>, flavonoid intakes have been reported to inversely associated with CVDs. In 2008, Hooper et al. performed a comprehensive review of reliable 133 flavonoid trials<ref name="Hooper">Hooper L, Kroon PA, Rimm EB, et al. "Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials" Am J Clin Nutr 88:38–50</ref>, and concluded that
* flavanol-rich cocoa reduces blood pressure by 6 (systolic) and 3 (diastolic) mm Hg,
* soy protein, which is rich in isoflavones, reduces LDL cholesterol by 0.2 mmol/L,
* black tea acutely (not chronic) raises blood pressure by 6 (systolic) and 3 (diastolic) mm Hg, and
* chocolate acutely (not chronic) increases flow-mediated dilation (FMD) by 4%.
At least, cocoa and soy (not tea) provide evidence for beneficial effects on CVD. However, it remains unclear whether the effects can be attributed to the specific flavonoid species<ref name="Geleijnse">Geleijnse JM, Hollman PCH (2008) "Flavonoids and cardiovascular health: which compounds, what mechanisms?" Am J Clin Nutr 88:12-13</ref>. A large scale cohort study (34789 men) found no association with flavonoids and CVD <ref name="Rimm">Rimm EB, Katan MB (1996) "Relation between intake of flavonoids and risk for coronary heart disease in male health professionals" Ann Intern Med 125(5):384-389 and Huxley RR, Neil HA (2003) "The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies" Eur J Clin Nutr 57:904–908</ref>.
|
ウーロン茶は血圧降下に効くと信じられているようです。
Hertog MGらの研究以後<ref name="Hertog"/>フラボノイドの摂取は循環器疾患に良いとされてきました。
2008年、Hooperらが信頼できる133 のフラボノイド研究を再調査し以下の結論を導きました<ref name="Hooper"/>。
* フラバノールが多いココアは血圧を 6 (収縮期)、 3 (拡張期) mm Hg下げる
* イソフラボンの多い大豆プロテインはLDLコレステロールを 0.2 mmol/L下げる
* 紅茶は一時的に血圧を 6 (収縮期) 、 3 (拡張期) mm Hg上げる
* チョコレートは一時的にFMD(血流依存性血管拡張)を4%上げる
お茶ではなくココアや大豆等がCVDに良い効果を与えることは示されていますが、具体的にフラボノイドが原因かどうかは明らかではありません<ref name="Geleijnse"/>。大規模なコホート研究では (34789 men)フラボノイドと循環器疾患の関係は見出されませんでした<ref name="Rimm"/>。
}}

;References
<references/>

===Obesity 肥満===
{{Twocolumn|
Recently, resveratrol is found to improve obesity.<ref name="Baur">Baur JA et al. Sinclair DA (2006) "Resveratrol improves health and survival of mice on a high-calorie diet" Nature 444:337-342</ref>. Some studies suggest relationship between green tea consumption and reduction in body fat<ref name="Wu">Wu CH, Lu FH et al. (2003) "Relationship among habitual tea consumption, percent body fat, and body fat distribution" Obes Res 11:1088-1095</ref><ref name ="Tian">Tian WX, Li LC et al. (2004) "Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase" Life Sci 74:2389-2399</ref>, but clear evidence on body weight control is missing. Since body weight may change for various reasons, it is hard to conduct an epidemiologic study.
|
近年レスベラトロールが肥満に効果があるという報告があります<ref name="Baur"/>。緑茶と体脂肪減少の関係を報告する論文もありますが<ref name="Wu"/><ref name="Tian"/>明白な関係はわかりません。体重は様々な要因で変化しやすいので疫学的調査も困難です。
}}

;References
<references/>

@@ Line 60: / Line 60: @@
 }}
 <references/>
@@ Line 70: / Line 69: @@
+|
 主にラットを用いた多くの動物実験では、お茶がコレステロール量を下げることが報告されています。この原因はカテキン類と考えられています。
-* 実験用Sprague-Dawleyラットにおいて、血漿中のトリアシルグリセロール、コレステロール、LDLコレステロールを下げるという報告<ref name="kuo"/>
+* 実験用Sprague-Dawleyラットにおいて、血漿中のトリアシルグリセロール、コレステロール、LDLコレステロールを下げるという報告
-* 実験用ラットにおいて、血清中、肝臓内のコレステロール低下（ただしHDL-コレステロール、トリアシルグリセロールは変化なし）という報告<ref name="yang"/>
+* 実験用ラットにおいて、血清中、肝臓内のコレステロール低下（ただしHDL-コレステロール、トリアシルグリセロールは変化なし）という報告
 }}
-;References
 <references/>
@@ Line 81: / Line 80: @@
 Recently, resveratrol is found to improve obesity.<ref name="Baur">Baur JA et al. Sinclair DA (2006) "Resveratrol improves health and survival of mice on a high-calorie diet" Nature 444:337-342</ref>. Some studies suggest relationship between green tea consumption and reduction in body fat<ref name="Wu">Wu CH, Lu FH et al. (2003) "Relationship among habitual tea consumption, percent body fat, and body fat distribution" Obes Res 11:1088-1095</ref><ref name ="Tian">Tian WX, Li LC et al. (2004) "Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase" Life Sci 74:2389-2399</ref>, but clear evidence on body weight control is missing. Since body weight may change for various reasons, it is hard to conduct an epidemiologic study.
+|
-近年レスベラトロールが肥満に効果があるという報告があります<ref name="Baur"/>。緑茶と体脂肪減少の関係を報告する論文もありますが<ref name="Wu"/><ref name="Tian"/>明白な関係はわかりません。体重は様々な要因で変化しやすいので疫学的調査も困難です。
+近年レスベラトロールが肥満に効果があるという報告があります。緑茶と体脂肪減少の関係を報告する論文もありますが、明白な関係はわかりません。体重は様々な要因で変化しやすいので疫学的調査も困難です。
 }}
 <references/>

@@ Line 1: / Line 1: @@
-[[Doc:Tea| Back to Tea Page (お茶のページに戻る)]]
+{{Tea/Header}}
-===Tea and Human Health <small>(健康情報)</small>===
-==Cancer 癌==
+==={{Bilingual|健康情報|Tea and Human Health}}===
 {{Twocolumn|None of the large-scale epidemiological studies found a significant association of tea intake with a lower risk of cancer<ref name="Borrelli">Borrelli F, Capasso R et al. (2004) "Systematic review: green tea and gastrointestinal cancer risk" Aliment Pharmacol Ther 19:497-510 PMID 14987318</ref>. However, many case-control studies and cross-sectional studies (up to several hundreds people) show a decrease of the risk of cancer.
+|
@@ Line 23: / Line 24: @@
 <references/>
-==Cardiovascular Disease (CVD) 循環器疾患==
+=={{Bilingual|循環器疾患|Cardiovascular Disease (CVD)}}==
 {{Twocolumn|
 It is often believed that (oolong) tea possesses hypotensive effects.
@@ Line 62: / Line 63: @@
 <references/>
-==Hypercholesterolemia 高コレステロール血症==
+=={{Bilingual|高コレステロール血症|Hypercholesterolemia}}==
 {{Twocolumn|
 In many animal studies, usually rats, various tea suppresses cholesterol levels. Catechins are considered to account for the hypocholesterolemic effect.
@@ Line 76: / Line 77: @@
-==Obesity 肥満==
+=={{Bilingual|肥満|Obesity}}==
 {{Twocolumn|
 Recently, resveratrol is found to improve obesity.<ref name="Baur">Baur JA et al. Sinclair DA (2006) "Resveratrol improves health and survival of mice on a high-calorie diet" Nature 444:337-342</ref>. Some studies suggest relationship between green tea consumption and reduction in body fat<ref name="Wu">Wu CH, Lu FH et al. (2003) "Relationship among habitual tea consumption, percent body fat, and body fat distribution" Obes Res 11:1088-1095</ref><ref name ="Tian">Tian WX, Li LC et al. (2004) "Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase" Life Sci 74:2389-2399</ref>, but clear evidence on body weight control is missing. Since body weight may change for various reasons, it is hard to conduct an epidemiologic study.
@@ Line 85: / Line 86: @@
 ;References
 <references/>

@@ Line 3: / Line 3: @@
 ==Cancer 癌==
-{{Twocolumn|None of the large-scale epidemiological studies found a significant association of tea intake with a lower risk of cancer<ref name="Borrelli">Borrelli F, Capasso R et al. (2004) "Systematic review: green tea and gastrointestinal cancer risk" Aliment Pharmacol Ther 19:497-510</ref>. However, many case-control studies and cross-sectional studies (up to several hundreds people) show a decrease of the risk of cancer.
+{{Twocolumn|None of the large-scale epidemiological studies found a significant association of tea intake with a lower risk of cancer<ref name="Borrelli">Borrelli F, Capasso R et al. (2004) "Systematic review: green tea and gastrointestinal cancer risk" Aliment Pharmacol Ther 19:497-510 PMID 14987318</ref>. However, many case-control studies and cross-sectional studies (up to several hundreds people) show a decrease of the risk of cancer.
+|
-いずれの大規模疫学調査においても、お茶を飲む習慣と低い癌リスクの相関は見出されていません<ref name="Borrelli"/>。ただし、多くの症例コントロール研究や横断的研究で癌リスクの低下は報告されています。<br/>
+いずれの大規模疫学調査においても、お茶を飲む習慣と低い癌リスクの相関は見出されていません。
 }}
 * Breast cancer 乳がん
-:: Two prospective studies with 35,004 women <ref>Suzuki Y, Tsubono Y et al. (2004) "Gren tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan" Br J Cancer 90:1361-1363</ref> &rarr; no association
+:: Two prospective studies with 35,004 women <ref>Suzuki Y, Tsubono Y et al. (2004) "Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan" Br J Cancer 90:1361-1363 PMID 15054454</ref> &rarr; no association
 * Gastrointestinal cancer 胃腸がん
-:: Prospective cohort 14873 men and 23667 women <ref name="Nagano">Nagano J, Kono S et al. (2001) "A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan)" Cancer Causes Control 12:501-508</ref> &rarr; no association
+:: Prospective cohort 14873 men and 23667 women <ref name="Nagano">Nagano J, Kono S et al. (2001) "A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan)" Cancer Causes Control 12:501-508 PMID 11519758</ref> &rarr; no association
-:: Prospective cohort 11902 men and 14409 women <ref>Tsubono Y, Nishino Y et al. (2001) "Green tea and the risk of gastric cancer in Japan" New Engl J Med 344:632-636</ref> &rarr; no association
+:: Prospective cohort 11902 men and 14409 women <ref>Tsubono Y, Nishino Y et al. (2001) "Green tea and the risk of gastric cancer in Japan" New Engl J Med 344:632-636 PMID 11228277</ref> &rarr; no association
-:: Prospective cohort 30370 men and 42481 women <ref>Hoshiyama Y, Kawaguchi T et al. (2002) "A prospective study of stomach cancer death in relation to green tea consumption in Japan" Br J Cancer 87:309-313</ref> &rarr; no association
+:: Prospective cohort 30370 men and 42481 women <ref>Hoshiyama Y, Kawaguchi T et al. (2002) "A prospective study of stomach cancer death in relation to green tea consumption in Japan" Br J Cancer 87:309-313 PMID 12177800</ref> &rarr; no association
-:: Prospective cohort 18746 men and 26184 women <ref>Fujino Y, tamakoshi A et al. (2002) "Prospective study of education background and stomach cancer in Japan" Prev Med 35:121-127</ref> &rarr; no association
+:: Prospective cohort 18746 men and 26184 women <ref>Fujino Y, tamakoshi A et al. (2002) "Prospective study of educational background and stomach cancer in Japan" Prev Med 35:121-127 PMID 12200096</ref> &rarr; no association
 * Bladder cancer 膀胱がん
 :: Prospective cohort 14873 men and 23667 women <ref name="Nagano"/> &rarr; no association

@@ Line 30: / Line 30: @@
 flavonoid intakes have been reported to inversely associated with CVDs.
 In 2008, Hooper et al. performed a comprehensive review of reliable 133 flavonoid trials
-<ref name="Hooper">Hooper L, Kroon PA, Rimm EB, et al. "Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials" Am J Clin Nutr 88:38–50 PMID 18614722</ref>,
+<ref name="Hooper">Hooper L, Kroon PA, Rimm EB, et al. (2008) "Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials" Am J Clin Nutr 88:38–50 PMID 18614722</ref>,
   and concluded that
 * flavanol-rich cocoa reduces blood pressure by 6 (systolic) and 3 (diastolic) mm Hg,

@@ Line 25: / Line 25: @@
 {{Twocolumn|
 It is often believed that (oolong) tea possesses hypotensive effects.
-After Hertog MG et al.<ref name="Hertog">Hertog MG, Feskens EJ (1993) "Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study" Lancet 342(8878):1007-1011</ref>, flavonoid intakes have been reported to inversely associated with CVDs. In 2008, Hooper et al. performed a comprehensive review of reliable 133 flavonoid trials<ref name="Hooper">Hooper L, Kroon PA, Rimm EB, et al. "Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials" Am J Clin Nutr 88:38–50</ref>, and concluded that
+After Hertog MG et al.
 * flavanol-rich cocoa reduces blood pressure by 6 (systolic) and 3 (diastolic) mm Hg,
 * soy protein, which is rich in isoflavones, reduces LDL cholesterol by 0.2 mmol/L,
 * black tea acutely (not chronic) raises blood pressure by 6 (systolic) and 3 (diastolic) mm Hg, and
 * chocolate acutely (not chronic) increases flow-mediated dilation (FMD) by 4%.
+|
 烏龍茶は血圧降下に効くと信じられているようです。
-Hertog MGらの研究以後<ref name="Hertog"/>フラボノイドの摂取は循環器疾患に良いとされてきました。
+Hertog MGらの研究以後、フラボノイドの摂取量と循環器疾患の率は逆相関の関係にあると言われてきました。
-年、Hooperらが信頼できる133 のフラボノイド研究を再調査し以下の結論を導きました<ref name="Hooper"/>。
+しかし2008年、Hooperらが信頼できる133 のフラボノイド研究を再調査し以下の結論を導いています。
 * フラバノールが多いココアは血圧を 6 (収縮期)、 3 (拡張期) mm Hg下げる
 * イソフラボンの多い大豆プロテインはLDLコレステロールを 0.2 mmol/L下げる
 * 紅茶は一時的に血圧を 6 (収縮期) 、 3 (拡張期) mm Hg上げる
 * チョコレートは一時的にFMD(血流依存性血管拡張)を4%上げる
 }}
 ;References