http://metabolomics.jp/mediawiki/index.php?action=history&feed=atom&title=Doc%3AAlcohol%2FWineDoc:Alcohol/Wine - Revision history2026-04-28T09:02:05ZRevision history for this page on the wikiMediaWiki 1.19.1http://metabolomics.jp/mediawiki/index.php?title=Doc:Alcohol/Wine&diff=171591&oldid=prevAdm at 07:32, 22 September 20102010-09-22T07:32:02Z<p></p>
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<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div>=={{Bilingual|<del class="diffchange diffchange-inline">French Paradox</del>|<del class="diffchange diffchange-inline">フレンチパラドックス</del>}}==</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>=={{Bilingual|<ins class="diffchange diffchange-inline">ワインとポリフェノール</ins>|<ins class="diffchange diffchange-inline">Wine and Phenolics</ins>}}==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div>{<del class="diffchange diffchange-inline">{Twocolumn</del>|</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>{| <ins class="diffchange diffchange-inline">class="wikitable"</ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">French Paradox refers to the potential health benefits </del>of <del class="diffchange diffchange-inline">moderate </del>wine <del class="diffchange diffchange-inline">consumption, because of the low risk of coronary heart diseases in France or moderate wine drinkers. This observation was associated with resveratrol, which was reported to activate [http://en.wikipedia.org</del>/<del class="diffchange diffchange-inline">wiki/Sirtuin Sirtuin] (or Sir2</del>) <del class="diffchange diffchange-inline">protein, a histone deacetylase implicated in anti-aging or prelonging life-span</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">! colspan="3" | Major phenolic constituents </ins>of wine <ins class="diffchange diffchange-inline">(mg </ins>/ <ins class="diffchange diffchange-inline">l</ins>)<ref><ins class="diffchange diffchange-inline">Frankel EN</ins>, <ins class="diffchange diffchange-inline">Waterhouse AL</ins>, <ins class="diffchange diffchange-inline">Teissedre P </ins>(<ins class="diffchange diffchange-inline">1995</ins>) ''<ins class="diffchange diffchange-inline">J Agric Food </ins>Chem'' <ins class="diffchange diffchange-inline">43, 890-894</ins></ref></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><ref><del class="diffchange diffchange-inline">Howitz et al. (2003) "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan" ''Nature'' 425:191-196</ref>. Sirtuin activation</del>, <del class="diffchange diffchange-inline">however</del>, <del class="diffchange diffchange-inline">has been the subject of controversy <ref>Kaeberlein M & Kennedy BK </del>(<del class="diffchange diffchange-inline">2007</del>) <del class="diffchange diffchange-inline">"Does resveratrol activate yeast Sir2 in vivo?" ''Aging Cell'' 6:415–416</ref><ref>Beher D et al. (2009) "Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity" </del>''Chem <del class="diffchange diffchange-inline">Biol Drug Des</del>'' <del class="diffchange diffchange-inline">74:619–624</del></ref><del class="diffchange diffchange-inline">. Even when it is true, the biological activity of less than 5 mg/l resveratrol in </del>wine <del class="diffchange diffchange-inline">needs further study.  Also, it is hard to extrapolate the yeast studies into human health</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div>|</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">! Phenolics || red </ins>wine <ins class="diffchange diffchange-inline">|| white wine</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| catechin || 191 || 35</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| epicatechin || 82 || 21</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| gallic acid || 95 || 7 </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| cyanidin || 3 || 0</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| malvidin 3-glucoside || 24 || 1</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| rutin || 9 || 0</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| quercetin || 8 || 0</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| myricetin || 9 || 0</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| resveratrol || 1</ins>.<ins class="diffchange diffchange-inline">5 || 0</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>|<ins class="diffchange diffchange-inline">}</ins></div></td></tr>
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<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">}</del>}</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">{| class="wikitable"</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">! colspan="2" | Total antioxidant activity of wines (mM)<ref>Rice-Evans C, Miller NJ, Paganga G (1996) ''Free Rad Biol Med'' 20, 933-956</ref> (may vary over a factor of 2)</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| Californian Pinot Noir, Rioja, Bouzy Rouge || 12-14</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| Australian Shiraz || 16</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| Bordeaux and Chianti || 23</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|-</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">| Green tea || 4</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">|</ins>}</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><references/></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=={{Bilingual|フレンチパラドックス|French Paradox}}==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">{{Twocolumn|</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">French Paradox refers to the potential health benefits of moderate wine consumption, because of the low risk of coronary heart diseases in moderate wine drinkers. This observation was associated with resveratrol, which was reported to activate [http://en.wikipedia.org/wiki/Sirtuin Sirtuin] (or Sir2) protein, a histone deacetylase implicated in anti-aging or prelonging life-span</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <ref>Jang M et al. Pezzuto JM (1997) "Cancer chemopreventive activity of resveratrol, a natural product derived from grapes" ''Science'' 275(5297):218-220</ref><ref>Howitz et al. (2003) "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan" ''Nature'' 425:191-196</ref><ref>Baur JA et al. Sinclair DA (2006) "Resveratrol improves health and survival of mice on a high-calorie diet" ''Nature'' 444:337-342</ref>. Sirtuin activation, however, has been the subject of controversy <ref>Kaeberlein M & Kennedy BK (2007) "Does resveratrol activate yeast Sir2 in vivo?" ''Aging Cell'' 6:415–416</ref><ref>Beher D et al. (2009) "Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity" ''Chem Biol Drug Des'' 74:619–624</ref>. Even when it is true, the biological activity of scarce (less than 5 mg/l) and rapidly metabolizing resveratrol in wine needs further study. In more recent study, resveratrol is known to inhibit COX-1 (cyclo-oxygenase-1) and COX-2, NAD+-dependent histone deacetylase SIRT1 (sirtuin 1) and QR2 (quinone reductase 2)</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><ref> Calamini B et al. (2010) "Pleiotropic mechanisms facilitated by resveratrol and its metabolites" ''Biochem J'' 429:273–282</ref>.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">|</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">フレンチパラドックスとは、赤ワインを適量飲む人が心臓疾患に罹る率が低い現象を指して言います。</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">この原因は、レスベラトロール (resveratrol) がヒストンのアセチル化を防ぐタンパク質であるSirtuin (またはSir2) を活性化させて抗老化、すなわち寿命を延ばすからとされましたが、そのメカニズムや効果については様々な反論があります。</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">もしSir2を活性化させるとしても、ワイン1リットルに5mgしか含まれず、体内から速やかに排出されるレスベラトロールの効果を明らかにするには更なる研究が必要です。</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">最新の研究では、レスベラトロールがCOX-1 (シクロオキシゲナーゼ1), COX-2, NAD+依存型ヒストン脱アセチル酵素 SIRT1 (sirtuin 1), そしてキノン還元酵素 QR2 を活性化することが報告されています。</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">}}</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">It bounds to cyclooxygenase-1, and may exert chemopreventive activity (Biochem J DOI:10.1042</del>/<del class="diffchange diffchange-inline">BJ20091857 See also Science 1997, 275, 218)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"><references</ins>/<ins class="diffchange diffchange-inline">></ins></div></td></tr>
</table>Admhttp://metabolomics.jp/mediawiki/index.php?title=Doc:Alcohol/Wine&diff=171590&oldid=prevAdm: Doc:Wine moved to Doc:Alcohol/Wine2010-09-22T06:57:04Z<p><a href="/wiki/Doc:Wine" class="mw-redirect" title="Doc:Wine">Doc:Wine</a> moved to <a href="/wiki/Doc:Alcohol/Wine" title="Doc:Alcohol/Wine">Doc:Alcohol/Wine</a></p>
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<td colspan='1' style="background-color: white; color:black;">Revision as of 06:57, 22 September 2010</td>
</tr></table>Admhttp://metabolomics.jp/mediawiki/index.php?title=Doc:Alcohol/Wine&diff=171589&oldid=prevAdm: New page: =={{Bilingual|French Paradox|フレンチパラドックス}}== {{Twocolumn| French Paradox refers to the potential health benefits of moderate wine consumption, because of the low risk o...2010-09-22T06:51:57Z<p>New page: =={{Bilingual|French Paradox|フレンチパラドックス}}== {{Twocolumn| French Paradox refers to the potential health benefits of moderate wine consumption, because of the low risk o...</p>
<p><b>New page</b></p><div>=={{Bilingual|French Paradox|フレンチパラドックス}}==<br />
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{{Twocolumn|<br />
French Paradox refers to the potential health benefits of moderate wine consumption, because of the low risk of coronary heart diseases in France or moderate wine drinkers. This observation was associated with resveratrol, which was reported to activate [http://en.wikipedia.org/wiki/Sirtuin Sirtuin] (or Sir2) protein, a histone deacetylase implicated in anti-aging or prelonging life-span<br />
<ref>Howitz et al. (2003) "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan" ''Nature'' 425:191-196</ref>. Sirtuin activation, however, has been the subject of controversy <ref>Kaeberlein M & Kennedy BK (2007) "Does resveratrol activate yeast Sir2 in vivo?" ''Aging Cell'' 6:415–416</ref><ref>Beher D et al. (2009) "Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity" ''Chem Biol Drug Des'' 74:619–624</ref>. Even when it is true, the biological activity of less than 5 mg/l resveratrol in wine needs further study. Also, it is hard to extrapolate the yeast studies into human health.<br />
|<br />
<br />
}}<br />
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It bounds to cyclooxygenase-1, and may exert chemopreventive activity (Biochem J DOI:10.1042/BJ20091857 See also Science 1997, 275, 218)</div>Adm