Category:PK - Revision history

Adm: /* Polyketide Synthase (PKS) */

2012-12-18T03:24:10Z

‎Polyketide Synthase (PKS)

Adm: /* {{Bilingual|構造|Structure}} */

2012-12-18T03:05:49Z

‎{{Bilingual|構造|Structure}}

Adm: /* {{Bilingual|構造|Structure}} */

2012-12-18T03:05:23Z

‎{{Bilingual|構造|Structure}}

Adm: /* Classification */

2012-04-12T14:55:51Z

‎Classification

Adm at 01:35, 3 December 2011

2011-12-03T01:35:47Z

Adm: /* {{Bilingual|タイプ|Type}} */

2011-09-06T13:57:17Z

‎{{Bilingual|タイプ|Type}}

Adm: /* {{Bilingual|タイプ I|Type I}} */

2011-09-06T02:16:32Z

‎{{Bilingual|タイプ I|Type I}}

Adm: /* Polyketide Synthase (PKS) */

2011-06-04T07:07:10Z

‎Polyketide Synthase (PKS)

Show changes

Adm at 05:57, 4 June 2011

2011-06-04T05:57:18Z

Adm at 05:41, 31 May 2011

2011-05-31T05:41:02Z

@@ Line 258: / Line 258: @@
 ---->
-==Polyketide Synthase (PKS) ==
+=Polyketide Synthase (PKS)=
-==={{Bilingual|分布|Distribution}}===
 {{Twocolumn|
 PKS members are found in bacteria, fungi, plants, slime mold<ref>Zucko J, Skunca N, Curk T, Zupan B, Long PF et al (2007) "Polyketide synthase genes and the natural products potential of Dictyostelium discoideum" ''Bioinformatics'' 23:2543-49</ref>, Alveolata<ref>Zhu G, LaGier MJ, Stejskal F, Millership JJ, Cai X et al (2002) "Cryptosporidium parvum: the first protist known to encode a putative polyketide synthase" ''Gene'' 298:79-89</ref>, and animals <ref>Castoe TA, Stephens T, Noonan BP, Calestani C (2007) "A novel group of type I polyketide synthases (PKS) in animals and the complex phylogenomics of PKSs" ''Gene'' 392:47-58</ref><ref>Calestani C, Rast JP, Davidson EH (2003) "Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening" ''Development'' 130:4587-96</ref>.
@@ Line 289: / Line 290: @@
 <references/>
-==={{Bilingual|タイプ|Type}}===
+=={{Bilingual|タイプ|Type}}==
-{{Twocolumn
-|There are three types of PKSs known to date.
-|ポリケチド合成酵素には3つのタイプがあります。}}
-===={{Bilingual|タイプ I|Type I}}====
+===Type I and Type II PKS===
 {{Twocolumn|
-Multiple domains per protein (e.g. Erythromycin biosynthesis <ref> (2001) ''Nat Prod Rep'' 18:380</ref>)
+Multiple domains per protein (e.g. Erythromycin biosynthesis <ref> (2001) ''Nat Prod Rep'' 18:380</ref>). The gene cluster spans at least 60 kb and synthesize macrolides and aromatic structures.
 * Bacterial type I is '''modular''', i.e., each domain (or module) catalyses a specific transformation.
-** Non-reducing (NR) type produces aromatic polyketides
+* Fungal type I is '''iterative''', i.e., same domains are used multiple times to create large structures.
-** partially reducing (PR) type
-** highly reducing (HR) type
-** (cf. fully reducing cases are fatty acid synthases, FAS)
+|
-複数ドメインを持つタンパク質 （例．　エリスロマイシン合成酵素）。　少なくとも 60 kb 以上の大きなクラスターを形成し大きな環状化合物を作る。構造の修飾はやや限定的。
+複数ドメインを持つタンパク質 （例．エリスロマイシン合成酵素）。　少なくとも 60 kb 以上の大きなクラスターを形成し芳香環やマクロライドのような環状化合物を作る。構造の修飾はやや限定的。
 * バクテリアのタイプ I は、モジュール型
 * 菌類のタイプ I は反復型
 }}
-−
+|
-;NR-PKS
-: orsellinic acid
-−
-;PR-PKS
-: 6-methyl salicylic acid (MSA)
-−
-===={{Bilingual|タイプ II|Type II}}====
 {{Twocolumn|
   single domain per protein
@@ Line 327: / Line 319: @@
 }}
-===={{Bilingual|タイプ III|Type III}}====
+|}
 {{Twocolumn|
 Chalcone synthase-like in plants
@@ Line 336: / Line 330: @@
 }}
-===={{Bilingual|例外的なPKS|Unusual Type}}====
+==={{Bilingual|その他|Others}}===
 {{Twocolumn|
 ;Bacterial but iterative type I PKS for aromatic polyketide

@@ Line 10: / Line 10: @@
 {{Twocolumn|
 Polyketides are natural products with multiple ketone structures and synthesized from acetyl CoA. The synthetic pathway is called Acetate-Malonate Pathway.
-Well known products include various erythromycin (antibiotic), melanin (pigment), and aflatoxin (toxin).
+Well known products include erythromycin (antibiotic), melanin (pigment), and aflatoxin (toxin).
+|
 ポリケチドはケトン構造を複数持つ天然物のカテゴリーで、アセチルCoAから作られます。その生合成ステップは、酢酸-マロン酸経路と呼ばれています。代表例は抗生物質のエリスロマイシン、色素のメラニン、毒素のアフラトキシンです。

@@ Line 10: / Line 10: @@
 {{Twocolumn|
 Polyketides are natural products with multiple ketone structures and synthesized from acetyl CoA. The synthetic pathway is called Acetate-Malonate Pathway.
-Well known
+Well known products include various erythromycin (antibiotic), melanin (pigment), and aflatoxin (toxin).
+|
-ポリケチドはケトン構造を複数持つ天然物のカテゴリーで、アセチルCoAから作られます。その生合成ステップは、酢酸-マロン酸経路と呼ばれています。
+ポリケチドはケトン構造を複数持つ天然物のカテゴリーで、アセチルCoAから作られます。その生合成ステップは、酢酸-マロン酸経路と呼ばれています。代表例は抗生物質のエリスロマイシン、色素のメラニン、毒素のアフラトキシンです。
 }}

@@ Line 62: / Line 62: @@
 ==Classification==
 ===3-4th digits===
-<!----Antimycin
+Antimycin
 Elfamycin
 Kijanimicin
 Sorbicillin polymers
 {| class="wikitable"
@@ Line 256: / Line 256: @@
 |}
 </center>
 ==Polyketide Synthase (PKS) ==

← Older revision		Revision as of 01:35, 3 December 2011
Line 7:		Line 7:

	=={{Bilingual\|概要\|Overview}}==		=={{Bilingual\|概要\|Overview}}==
		+	==={{Bilingual\|構造\|Structure}}===
		+	{{Twocolumn\|
		+	Polyketides are natural products with multiple ketone structures and synthesized from acetyl CoA. The synthetic pathway is called Acetate-Malonate Pathway.
		+	Well known
		+	\|
		+	ポリケチドはケトン構造を複数持つ天然物のカテゴリーで、アセチルCoAから作られます。その生合成ステップは、酢酸-マロン酸経路と呼ばれています。
		+	}}

	==={{Bilingual\|酢酸-マロン酸経路\|Acetate-Malonate Pathway}}===		==={{Bilingual\|酢酸-マロン酸経路\|Acetate-Malonate Pathway}}===

@@ Line 301: / Line 301: @@
 ** 部分還元型 はそれ以外の構造を作る
 }}
 ===={{Bilingual|タイプ II|Type II}}====
@@ Line 346: / Line 352: @@
 }}
 * NonPQU and NonJK (''Streptomyces griseus'')<ref>Kwon HJ, Smith WC, Scharon AJ, Hwang SH, Kurth MJ, Shen B (2002) C-O bond formation by polyketide synthases ''Science'' 297(5585):1327-30</ref>
 ===Unusual structures===

@@ Line 6: / Line 6: @@
 |}
-==Class Overview==
+=={{Bilingual|概要|Overview}}==
 {{Twocolumn|
 Polyketides are synthesized through the polymerization of acetyl units (&beta;-ketomethylene) as in fatty acid  biosynthesis. Typical starter units are short-chain fatty acids (e.g. acetyl-CoA or propionyl-CoA), on to which extender units (e.g. malonyl-CoA or methylmalonyl-CoA) are repeatedly polymerized.
@@ Line 42: / Line 52: @@
+|
 最後に、チオエステル分解酵素 ('''TE''') によって伸張が止まり、ラクトン化 (閉環) します。
 }}